Rewiring cell signalling through chimaeric regulatory protein engineering
نویسندگان
چکیده
منابع مشابه
Rewiring cell signalling through chimaeric regulatory protein engineering
Bacterial cells continuously sense and respond to their environment using their inherent signalling and gene regulatory networks. Cells are equipped with parallel signalling pathways, which can specifically cope with individual input signals, while interconnectivities between pathways lead to an enhanced complexity of regulatory responses that enable sophisticated adaptation. In principle, any ...
متن کاملEngineering microbial phenotypes through rewiring of genetic networks
The ability to program cellular behaviour is a major goal of synthetic biology, with applications in health, agriculture and chemicals production. Despite efforts to build 'orthogonal' systems, interactions between engineered genetic circuits and the endogenous regulatory network of a host cell can have a significant impact on desired functionality. We have developed a strategy to rewire the en...
متن کاملRewiring through epidemic spreading
Structure and properties of networks, such as metabolic networks, human relations, and the Internet, have been attracting research interests in various research fields. Some common features have been found in those networks. The origins of such structure have been investigated. Dynamics in networks also have been studied so far. Preferential rewiring processes have been reported for generating ...
متن کاملRegulatory network rewiring by gene duplication
Thank you again for submitting your work to Molecular Systems Biology. We have now heard back from the three referees who agreed to evaluate your manuscript. As you will see from the reports below, the reviewers acknowledged that this work presents a potentially interesting and extensive analysis of phosphorylation network evolution in yeast. The reviewers, however, did raise a series of substa...
متن کاملEvolutionary rewiring of bacterial regulatory networks
Bacteria have evolved complex regulatory networks that enable integration of multiple intracellular and extracellular signals to coordinate responses to environmental changes. However, our knowledge of how regulatory systems function and evolve is still relatively limited. There is often extensive homology between components of different networks, due to past cycles of gene duplication, diverge...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2013
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20130138